Publications

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

Author(s): Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS|Journal: Cell|PMID: 29149604| November 2017

Cholesterol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER) due to its uniquely challenging biophysical properties. While…

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.

Author(s): Hotamisligil GS|Journal: Cell|PMID: 20303879| March 2010

The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking and is central to…

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

Author(s): Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS|Journal: Cell|PMID: 20144759| February 2010

As chronic inflammation is a hallmark of obesity, pathways that integrate nutrient- and pathogen sensing pathways are of great interest…

Stressing the brain, fattening the body.

Author(s): Yang L., Hotamisligil GS|Journal: Cell|PMID: 18854151| October 2008

Obesity is characterized by chronic activation of inflammatory pathways in peripheral tissues. In this issue, Zhang et al. (2008) demonstrate…

Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

Author(s): Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS|Journal: Cell|PMID: 18805087| September 2008

Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative lipidomic…

Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.

Author(s): Wellen KE, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS|Journal: Cell|PMID: 17482547| May 2007

Metabolic and inflammatory pathways crosstalk at many levels, and, while required for homeostasis, interaction between these pathways can also lead…

Through thick and thin: wasting, obesity, and TNF alpha.

Author(s): Spiegelman BM, Hotamisligil GS|Journal: Cell|PMID: 8500160| May 1993