Publications

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.

Author(s): Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS|Journal: Cell Rep|PMID: 29020626| October 2017

Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a…

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Author(s): Yang L., Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L|Journal: Cell Rep|PMID: 26774472| January 2016

Calorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum corticosterone and HSP70 expression in rodents. However,…

A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.

Author(s): Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS|Journal: Cell Rep|PMID: 25843719| April 2015

Aberrant stress and inflammatory responses are key factors in the pathogenesis of obesity and metabolic dysfunction, and the double-stranded RNA-dependent…

The role of adipocyte XBP1 in metabolic regulation during lactation.

Author(s): Gregor MF, Misch ES, Yang L., Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS|Journal: Cell Rep|PMID: 23623498| May 2013

The adipocyte is central to organismal metabolism and exhibits significant functional and morphological plasticity during its formation and lifespan. Remarkable…