ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity. Author(s): Garfinkel BP, Hotamisligil GS|Journal: Mol Cell|PMID: 28622517| June 2017 A new mechanism linking ER dysfunction to metabolic inflammation is discovered in a recent study by Shan et al. (2017), which…
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. Author(s): Ozcan U, Ozcan L, Yilmaz E, Düvel K, Sahin M, Manning BD, Hotamisligil GS|Journal: Mol Cell|PMID: 18342602| March 2008 Mammalian target of rapamycin, mTOR, is a major sensor of nutrient and energy availability in the cell and regulates a…
