Publications – The Hotamışlıgil Lab at the Sabri Ülker Center

METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.

Author(s): Yang L., Calay ES, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GSJournal: SciencePMID: 26228140 July 2015

The association between inflammation and endoplasmic reticulum (ER) stress has been observed in many diseases. However, if and how chronic…

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.

Author(s): Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GSJournal: SciencePMID: 16931765 August 2006

Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence…

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

Author(s): Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GSJournal: SciencePMID: 15486293 October 2004

Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and…

Function of GATA transcription factors in preadipocyte-adipocyte transition.

Author(s): Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, Hotamisligil GSJournal: SciencePMID: 11021798 October 2000

Genes that control the early stages of adipogenesis remain largely unknown. Here, we show that murine GATA-2 and GATA-3 are…

Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.

Author(s): Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BMJournal: SciencePMID: 8910278 November 1996

Fatty acid binding proteins (FABPs) are small cytoplasmic proteins that are expressed in a highly tissue-specific manner and bind to…

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance.

Author(s): Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BMJournal: SciencePMID: 8571133 February 1996

Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease…

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance.

Author(s): Hotamisligil GS, Shargill NS, Spiegelman BMJournal: SciencePMID: 7678183 January 1993

Tumor necrosis factor-alpha (TNF-alpha) has been shown to have certain catabolic effects on fat cells and whole animals. An induction…