Author(s): Hotamisligil GS|Journal: Nat Med|PMID:20376052| April 2010
Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention…
Author(s): Hotamisligil GS|Journal: Int J Obes (Lond)|PMID:19136991| December 2008
Obesity is associated with chronic low-grade inflammation. Inflammatory signals interfere with insulin action and disrupt metabolic homeostasis. The c-Jun N-terminal…
Author(s): Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS|Journal: Cell|PMID:18805087| September 2008
Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative lipidomic…