Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Author(s): Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Brüning J, Hertzel AV, Bernlohr DA, Hotamisligil GS|Journal: Diabetes|PMID: 12540600| February 2003 The metabolic syndrome is a cluster of metabolic and inflammatory abnormalities including obesity, insulin resistance, type 2 diabetes, hypertension, dyslipidemia,…
Altered tumor necrosis factor-alpha (TNF-alpha) processing in adipocytes and increased expression of transmembrane TNF-alpha in obesity. Author(s): Xu H, Uysal KT, Becherer JD, Arner P, Hotamisligil GS|Journal: Diabetes|PMID: 12031976| June 2002 Tumor necrosis factor-alpha (TNF-alpha) is synthesized as a 26-kDa transmembrane protein (mTNF-alpha), which may present on the cell surface or…
Altered insulin secretion associated with reduced lipolytic efficiency in aP2-/- mice. Author(s): Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek DR, Meyers DS, Morgan M, Parker RA, Hotamisligil GS|Journal: Diabetes|PMID: 10512363| October 1999 Recent studies have shown that genetic deficiency of the adipocyte fatty acid-binding protein (aP2) results in minor alterations of plasma…
Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Author(s): Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM|Journal: Diabetes|PMID: 9032102| March 1997 Previous studies have shown that tumor necrosis factor (TNF)-alpha production from adipose tissue is elevated in rodent and human obesity…
Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Author(s): Hotamisligil GS, Spiegelman BM|Journal: Diabetes|PMID: 7926300| November 1994 Recent data have suggested a key role for tumor necrosis factor (TNF)-alpha in the insulin resistance of obesity and non-insulin-dependent…
