Publications – Page 3 – The Hotamışlıgil Lab at the Sabri Ülker Center

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Author(s): Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YHJournal: Nat MedPMID: 28346411 May 2017

Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an…

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism.

Author(s): Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TSJournal: NaturePMID: 28219080 March 2017

Tissue-resident memory T (T) cells persist indefinitely in epithelial barrier tissues and protect the host against pathogens. However, the biological…

Inflammation, metaflammation and immunometabolic disorders.

Author(s): Hotamisligil GSJournal: NaturePMID: 28179656 February 2017

Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental…

Immune Cell Intolerance for Excess Cholesterol.

Author(s): Widenmaier SB, Hotamisligil GSJournal: ImmunityPMID: 28002726 December 2016

Chronic metabolic challenges have severe consequences on physiological systems. In this issue of Immunity, Ito et al. (2016) show that defects…

Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment.

Author(s): Ertunc ME, Hotamisligil GSJournal: J Lipid ResPMID: 27330055 December 2016

Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids, and triglycerides. These molecules represent a highly…

Cell Signaling and Stress Responses.

Author(s): Hotamisligil GS, Davis RJJournal: Cold Spring Harb Perspect BiolPMID: 27698029 October 2016

Stress-signaling pathways are evolutionarily conserved and play an important role in the maintenance of homeostasis. These pathways are also critical…

Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation.

Author(s): Çimen I, Kocatürk B, Koyuncu S, Tufanlı Ö, Onat UI, Yıldırım AD, Apaydın O, Demirsoy Ş, Aykut ZG, Nguyen UT, Watkins SM, Hotamisligil GS, Erbay EJournal: Sci Transl MedPMID: 27683551 September 2016

De novo lipogenesis (DNL), the conversion of glucose and other substrates to lipids, is often associated with ectopic lipid accumulation,…

De Novo Lipogenesis Products and Endogenous Lipokines.

Author(s): Yilmaz M, Claiborn KC, Hotamisligil GSJournal: DiabetesPMID: 27288005 July 2016

Recent studies have shown that in addition to their traditionally recognized functions as building blocks, energy stores, or hazardous intermediates,…

Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Author(s): Babaev VR, Yeung M, Erbay E, Ding L, Zhang Y, May JM, Fazio S, Hotamisligil GS, Linton MFJournal: Arterioscler Thromb Vasc BiolPMID: 27102962 June 2016

The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic…

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.

Author(s): Yang L., Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana LJournal: Cell RepPMID: 26774472 January 2016

Calorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum corticosterone and HSP70 expression in rodents. However,…