The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Author(s): Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YHJournal: Nat MedPMID: 28346411 May 2017
Brown adipose tissue (BAT) and beige adipose tissue combust fuels for heat production in adult humans, and so constitute an…

Immune Cell Intolerance for Excess Cholesterol.

Author(s): Widenmaier SB, Hotamisligil GSJournal: ImmunityPMID: 28002726 December 2016
Chronic metabolic challenges have severe consequences on physiological systems. In this issue of Immunity, Ito et al. (2016) show that defects…

Cell Signaling and Stress Responses.

Author(s): Hotamisligil GS, Davis RJJournal: Cold Spring Harb Perspect BiolPMID: 27698029 October 2016
Stress-signaling pathways are evolutionarily conserved and play an important role in the maintenance of homeostasis. These pathways are also critical…