Publications – Page 5 – The Hotamışlıgil Lab at the Sabri Ülker Center

Potential role for snoRNAs in PKR activation during metabolic stress.

Author(s): Youssef OA, Safran SA, Nakamura T, Nix DA, Hotamisligil GS, Bass BLJournal: Proc Natl Acad Sci U S APMID: 25848059 April 2015

Protein kinase RNA-activated (PKR) has long been known to be activated by viral double-stranded RNA (dsRNA) as part of the…

A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.

Author(s): Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GSJournal: Cell RepPMID: 25843719 April 2015

Aberrant stress and inflammatory responses are key factors in the pathogenesis of obesity and metabolic dysfunction, and the double-stranded RNA-dependent…

Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity.

Author(s): Ertunc ME, Sikkeland J, Fenaroli F, Griffiths G, Daniels MP, Cao H, Saatcioglu F, Hotamisligil GSJournal: J Lipid ResPMID: 25535287 February 2015

Adipocyte fatty acid binding protein 4, aP2, contributes to the pathogenesis of several common diseases including type 2 diabetes, atherosclerosis,…

Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity.

Author(s): Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GSJournal: Nat MedPMID: 25419710 December 2014

Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site has…

Coordinated regulation of protein synthesis and degradation by mTORC1.

Author(s): Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BDJournal: NaturePMID: 25043031 September 2014

Eukaryotic cells coordinately control anabolic and catabolic processes to maintain cell and tissue homeostasis. Mechanistic target of rapamycin complex 1…

FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues.

Author(s): Garin-Shkolnik T, Rudich A, Hotamisligil GS, Rubinstein MJournal: DiabetesPMID: 24319114 March 2014

Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes…

Aberrant islet unfolded protein response in type 2 diabetes.

Author(s): Engin F, Nguyen T, Yermalovich A, Hotamisligil GSJournal: Sci RepPMID: 24514745 February 2014

The endoplasmic reticulum adapts to fluctuations in demand and copes with stress through an adaptive signaling cascade called the unfolded…

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

Author(s): Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GSJournal: DiabetesPMID: 24150608 February 2014

Obesity and metabolic diseases appear as clusters, often featuring high risk for insulin resistance and type 2 diabetes, and constitute…

A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting.

Author(s): Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi MJournal: PLoS OnePMID: 24244493 November 2013

During prolonged fasting, fatty acid (FA) released from adipose tissue is a major energy source for peripheral tissues, including the…

Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes.

Author(s): Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GSJournal: Sci Transl MedPMID: 24225943 November 2013

Perturbations in endoplasmic reticulum (ER) homeostasis can evoke stress responses leading to aberrant glucose and lipid metabolism. ER dysfunction is…