Researchers from the Hotamışlıgil Lab and the Sabri Ülker Center at Harvard T.H. Chan School of Public Health have observed that one key adaptive response in the brown adipose tissue is through protein degradation, or simply put; eliminate cellular waste. The scientists also identified that this critical response system is operated by a molecular switch known as NRF1 that responds to cold or other activating signals to turn on the disposal facilities of the cell.
This study was published online on February 5, 2018 in Nature Medicine and featured in the March 2018 issue. Abstract: https://www.nature.com/articles/nm.4481