Publications

Sympathetic tone dictates the impact of lipolysis on FABP4 secretion.

Author(s): Prentice KJ, Lee A, Cedillo P, Inouye KE, Ertunc ME, Riveros JK, Lee GY, Hotamisligil GSJournal: J Lipid ResPMID: 37172691 July 2023

Levels of circulating FABP4 protein are strongly associated with obesity and metabolic disease in both mice and humans, and secretion…

Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion.

Author(s): Inouye KE, Prentice KJ, Lee A, Wang ZB, Dominguez-Gonzalez C, Chen MX, Riveros JK, Burak MF, Lee GY, Hotamisligil GSJournal: JCI InsightPMID: 37279064 July 2023

Fatty acid binding protein 4 (FABP4) is a lipid chaperone secreted from adipocytes upon stimulation of lipolysis. Circulating FABP4 levels…

Regulation of liver subcellular architecture controls metabolic homeostasis

Author(s): Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GSJournal: NaturePMID: 35264794 March 2022

Cells display complex intracellular organization by compartmentalization of metabolic processes into organelles, yet the resolution of these structures in the…

Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity.

Author(s): Güney E, Arruda AP, Parlakgül G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GSJournal: Sci SignalPMID: 34905386 December 2021

Chronic metabolic inflammation is a key feature of obesity, insulin resistance, and diabetes. Here, we showed that altered regulation of…

A hormone complex of FABP4 and nucleoside kinases regulates islet function.

Author(s): Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GSJournal: NaturePMID: 34880500 December 2021

The liberation of energy stores from adipocytes is critical to support survival in times of energy deficit; however, uncontrolled or…

Intercellular Transmission of Hepatic ER Stress in Obesity Disrupts Systemic Metabolism.

Author(s): Tirosh A, Tuncman G, Calay ES, Rathaus M, Ron I, Yalcin A, Lee YG, Livne R, Ron S, Minsky N, Arruda AP, Hotamisligil GSJournal: Cell MetabPMID: 33340456 December 2020

Endoplasmic reticulum stress (ERS) has a pathophysiological role in obesity-associated insulin resistance. Yet, the coordinated tissue response to ERS remains…

Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H₂ O₂ production in heart and skeletal muscle mitochondria.

Author(s): Goncalves RLS, Schlame M, Bartelt A, Brand MD, Hotamisligil GSJournal: FEBS LettPMID: 33112430 October 2020

Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the gene encoding the transacylase tafazzin and…