Publications – Page 2 – The Hotamışlıgil Lab at the Sabri Ülker Center

12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.

Author(s): Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YHJournal: Cell MetabPMID: 31353262 October 2019

Distinct oxygenases and their oxylipin products have been shown to participate in thermogenesis by mediating physiological adaptations required to sustain…

The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans.

Author(s): Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GSJournal: Sci Transl MedPMID: 31019023 April 2019

The short-chain fatty acid propionate is a potent inhibitor of molds that is widely used as a food preservative and…

Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses.

Author(s): Prentice KJ, Saksi J, Hotamisligil GSJournal: J Lipid ResPMID: 30705117 April 2019

Although counterregulatory hormones and mediators of the fight-or-flight responses are well defined at many levels, how energy stores per se…

TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis.

Author(s): Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu MJournal: DiabetesPMID: 29871859 August 2018

Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) is a receptor for the TNF superfamily cytokines, B cell-activating…

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity.

Author(s): Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GSJournal: Nat MedPMID: 29400713 March 2018

Adipocytes possess remarkable adaptive capacity to respond to nutrient excess, fasting or cold exposure, and they are thus an important…

Defective STIM-mediated store operated Ca²⁺ entry in hepatocytes leads to metabolic dysfunction in obesity.

Author(s): Arruda AP, Pers BM, Parlakgül G, Güney E, Goh T, Cagampan E, Lee GY, Goncalves RL, Hotamisligil GSJournal: ElifePMID: 29243589 December 2017

Defective Ca handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca level is in…

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.

Author(s): Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GSJournal: CellPMID: 29149604 November 2017

Cholesterol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER) due to its uniquely challenging biophysical properties. While…

Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.

Author(s): Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YHJournal: Nat MedPMID: 29117173 November 2017

This corrects the article DOI: 10.1038/nm.4297.

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins.

Author(s): Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GSJournal: Cell RepPMID: 29020626 October 2017

Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a…

Foundations of Immunometabolism and Implications for Metabolic Health and Disease.

Author(s): Hotamisligil GSJournal: ImmunityPMID: 28930657 September 2017

Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of…