Author(s): Chu NF, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB|Journal: Int J Obes Relat Metab Disord|PMID:11033975| September 2000
Leptin, an adipocyte-derived protein product of the obesity (ob) gene, is a multifunctional polypeptide associated with the development of obesity-related…
Author(s): Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GS|Journal: Proc Natl Acad Sci U S A|PMID:10884431| July 2000
Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor…
Tumour necrosis factor-alpha (TNFalpha) is a multifunctional cytokine that exerts a myriad of biological actions in numerous different tissues including…
Author(s): Samad F, Uysal KT, Wiesbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJ|Journal: Proc Natl Acad Sci U S A|PMID:10359811| June 1999
Obesity is associated with a cluster of abnormalities, including hypertension, insulin resistance, hyperinsulinemia, and elevated levels of both plasminogen activator…