The role of TNF alpha in adipocyte metabolism. Author(s): Sethi JK, Hotamisligil GS|Journal: Semin Cell Dev Biol|PMID: 10355025| February 1999 Tumor necrosis factor-alpha (TNF alpha) is a multifunctional cytokine which exerts a myriad of biological actions in different tissues and…
Stability of human plasma leptin concentrations within 36 hours following specimen collection. Author(s): Chu NF, Makowski L, Hotamisligil GS, Rimm EB|Journal: Clin Biochem|PMID: 10074899| February 1999
Mechanisms of TNF-alpha-induced insulin resistance. Author(s): Hotamisligil GS|Journal: Exp Clin Endocrinol Diabetes|PMID: 10320052| January 1999 There is now substantial evidence linking TNF-alpha to the presentation of insulin resistance in humans, animals and in vitro systems.…
Functional analysis of tumor necrosis factor (TNF) receptors in TNF-alpha-mediated insulin resistance in genetic obesity. Author(s): Uysal KT, Wiesbrock SM, Hotamisligil GS|Journal: Endocrinology|PMID: 9832419| December 1998 Although obesity has become the most common metabolic disorder in the developed world and is highly associated with insulin resistance…
Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. Author(s): Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS|Journal: J Clin Invest|PMID: 9389742| December 1997 Cytokines, in particular tumor necrosis factor-alpha (TNF-alpha), have significant effects on energy metabolism and appetite although their mechanisms of action…
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Author(s): Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS|Journal: Nature|PMID: 9335502| October 1997 Obesity is highly associated with insulin resistance and is the biggest risk factor for non-insulin-dependent diabetes mellitus. The molecular basis…
Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Author(s): Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM|Journal: Diabetes|PMID: 9032102| March 1997 Previous studies have shown that tumor necrosis factor (TNF)-alpha production from adipose tissue is elevated in rodent and human obesity…
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Author(s): Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM|Journal: Science|PMID: 8910278| November 1996 Fatty acid binding proteins (FABPs) are small cytoplasmic proteins that are expressed in a highly tissue-specific manner and bind to…
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. Author(s): Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM|Journal: J Biol Chem|PMID: 8662983| May 1996 Tumor necrosis factor (TNF)-alpha plays a central role in the state of insulin resistance associated with obesity. It has previously…
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Author(s): Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM|Journal: Science|PMID: 8571133| February 1996 Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease…
